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Recently, the first orally administered GLP-1 analogue was approved for the treatment of T2DM

Modifications in calorie intake or eating habits can have additional effects on hormone amounts and metabolic function

[1] Any weight loss greater than two pounds per week over several weeks is considered rapid weight loss

Moreover, GLP-1 could be involved in mechanisms of growth and expansion of IECs, as the loss of GLP-1Rs on IELs has been associated with shorter and smaller intestines in mice (59, 63, 64)