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It remains in Phase 3 clinical trials through the TRIUMPH program, which includes multiple studies examining different patient populations and endpoints

doi:10.1067/mcp.2002.121236

The mean GPA-R score was 1.75

This includes proteinuria ( 300 mg/24hr urine collection, protein/creatinine ratio of 3 mg/dL, or dipstick reading of 2+ protein if other methods are not available), thrombocytopenia ( 1.1 mg/dL), elevated liver enzymes (at least 2x upper limit of normal), pulmonary edema, or neurological symptoms (e.g., new onset headache not responding to medications or visual disturbances not attributable to another diagnosis)

During active weight loss, your dose gradually increases as your body builds tolerance to the medication's effects

Specialization in endocrinology is not necessary, though some patients prefer consulting specialists experienced in metabolic disorders