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Diabetologia (2017) 60:144253

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[26] [27] When starting GLP-1 treatment, many patients experience a significant reduction in appetite and early satietyfeeling full after consuming smaller portions

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Short courses are fine but chronic use defeats part of the mechanism

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10.1152/ajpregu.00732.2002 [DOI] [PubMed] [Google Scholar] Wilding, J

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Protein synthesis increases, catabolism decreases, and fat oxidation is prioritized for energy needs

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Since this is so rare a complication, in so few patients, it is difficult to delineate the exact mechanism

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