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When gut bacteria ferment dietary fiber in the colon, they produce these SCFAs, which directly activate L-cells to secrete GLP-1

As previously mentioned, they stabilize mitochondrial function and reduce oxidative stress, and inflammation by inhibiting signaling pathways, such as NF- B, thereby contributing to cellular homeostasis during sepsis (41)

Although proposed mechanismssuch as modulation of the HPA axis and central GLP1 receptor signallingsuggest potential antidepressant effects, clinical findings remain inconsistent

[DOI] [PubMed] [Google Scholar] 208.Jabbour S.A., Frias J.P., Guja C., Hardy E., Ahmed A., Ohman P

HCPs must be aware of the possibility of these rare side effects to act early and avoid the complications related to volume depletion, such as severe renal failure [62,63]

The final biological evaluation confirmed that compound 62 (Figure 7) possessed the highest enzyme inhibitory activity, with an IC 50 of 2.5 nM