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At the 10 mg dose, participants achieved approximately 22% body weight reduction over 72 weeks

These real-world data are vital for identifying new safety signals and confirming known risks across diverse populations

According to the UK SmPC, the most frequently reported adverse effects include: Gastrointestinal side effects (very common, affecting more than 1 in 10 people): Nausea often most pronounced during the initial weeks of treatment or following dose escalation Diarrhoea may be mild to moderate and typically improves with continued use Vomiting can occur, particularly if dietary modifications are not made Constipation less common than diarrhoea but reported in some patients Abdominal pain or discomfort usually transient Decreased appetite a therapeutic effect contributing to weight loss but may be troublesome for some These gastrointestinal symptoms are generally dose-dependent and tend to diminish over time as the body adapts to the medication

We compare it directly with psyllium in chicory inulin vs psyllium husk, and the regulatory detail is in our EFSA health claims explainer

Following this analysis, we will develop a customized plan encompassing vitamin/supplement optimization, prescribed medication, and lifestyle adjustments tailored to restore optimal balance and function

Autophagy in adipose tissue physiology and pathophysiology