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For example, GLP-1R in adipocytes can directly regulate apoptosis and preadipocyte proliferation by activating the adenylate cyclase/cyclic adenosine monophosphate (AC/cAMP) signaling pathway and various cell signaling cascades, including extracellular signal-regulated kinase (ERK), protein kinase C (PKC), and protein kinase B (AKT) [41,46]

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GLP-1 receptor agonists (GLP-1RAs) has the similar physiological function of GLP-1

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Some newer medications in this class also target additional hormones like GIP (Glucose-Dependent Insulinotropic Polypeptide)

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I think it sends a really terrible message to the public, which just kind of reinstates the stigma around obesity, saying that this is not a disease, this is a choice, she said

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In summary, the oral GLP-1 pill is not only available but also expanding in use

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