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It is a potential treatment for various complement-mediated kidney diseases, including primary IgA nephropathy (IgAN), C3 glomerulopathy (C3G), and immune-complex mediated membranoproliferative glomerulonephritis (IC-MPGN)
Within the Hallmarks of Aging framework, their effects are most evident across metabolic, inflammatory, and mitochondrial pathways that connect cellular stress to systemic dysfunction
39 For example, semaglutide may be selected for Medicare price negotiation under the IRA as early as 2025, with negotiated prices potentially taking effect as early as 2027
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