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Once you remove a tirzepatide vial from the refrigerator, it can remain at room temperature (up to 77F or 25C) for up to 28 days, depending on your specific product instructions

The risk of using degraded peptide, reduced effectiveness, unpredictable dosing, potential contamination, always outweighs the cost of a replacement vial

doi: 10.1016/j.pharep.2018.11.001 26 PhillipsAClementsJN

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Therefore, the net effect of tirzepatide in T2DM is a reduction in inappropriately high glucagon levels, likely due to the predominant GLP-1R-mediated suppression
