glp 1 muscle loss Weight with GLP-1 medicines does not result in a disproportionate loss of mass or function in obese mice and humans Most of the “muscle loss”

doi:10.3389/fcimb.2020.588517 Habtemariam S

Both medications can increase the risk of hypoglycemia when used alongside insulin or insulin secretagogues, so blood glucose levels should be monitored closely

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10.1124/jpet.121.001152 21

However, in animals devoid of both GLP-1 and glucagon, insulin response to an intravenous and oral glucose load appear to be normal suggesting that GLP-1 and glucagon, together, are not necessary for insulin secretion and/or that redundant in vivo mechanism are able to compensate (27)

The GI side effects could exacerbate underlying conditions