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While these effects are beneficial in metabolic regulation, they also underline the most reported adverse effects, namely, nausea, vomiting, and diarrhea, all gastro-intestinal related, particularly during the initiation or rapid dose escalation of therapy
doi:10.7759/cureus.101693 Min JS, Jo SJ, Lee S, et al
Enhanced Insulin Secretion: Activation of both GIP and GLP-1 receptors stimulates glucose-dependent insulin release from pancreatic -cells, improving postprandial and fasting glycemia while minimizing the risk of hypoglycemia
Weinstein J, Girard L-P, Lepage S, McKelvie RS, Tennankore K
Rosenstock J, Aronson R, Grunberger G, et al
The post-prandial stimulation of glucose is not only promoted by the post-prandial rise in glucose concentrations, but also by the gastrointestinal hormones glucagon-like peptide-1 (GLP-1) and gastric inhibitory polypeptide (GIP)
