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The subjects who, at that time, switched from semaglutide 2.4mg to placebo had regained half of that weight after 48 weeks, whereas those who continued on active treatment achieved an additional weight loss of around 8% in the same time period

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In the SURMOUNT-5 trial, mean weight change at 72 weeks was greater with tirzepatide

Therapeutic considerations Maximal effect seen within 1015 days Adverse effects include allergic reactions, lacrimation, conjunctivitis and salivary gland pain Key prescribing point Iodide is used as a shortterm adjunct , and longterm use should be avoided due to loss of antithyroid efficacy

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