semaglutide efficacy weight loss Outcome of and liraglutide The left graph shows Differential efficacy of weight loss

Trials show people on semaglutide (the active ingredient in modern weight-loss drugs) consume 24% fewer calories per day

A medical consultation is needed to determine whether treatment is appropriate for you

Our study included more recent RCTs on SGLT-2 inhibitors, such as the Sotagliflozin on Cardiovascular and Renal Events in Patients with Type 2 Diabetes and Moderate Renal Impairment Who Are at Cardiovascular Risk (SCORED) and Sotagliflozin on Cardiovascular Events in Patients with Type 2 Diabetes Post Worsening Heart Failure (SOLOIST-WHF) trials, which may have contributed to this mixed result

Semaglutide works on one receptor (GLP-1)

According to our sensitivity analysis, the maximum weekly drug dose would expand to 10 mg/week if the oral bioavailability was increased by 10 fold or the manufacturing cost was reduced by 10 fold

Your prescriber may recommend dose escalation, switching to tirzepatide, or combining both through PlexusDx's GLP-Squared option