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These factors include increased accumulation of advanced glycation end products (AGEs), chronic inflammation due to increased proinflammatory cytokines, and bone microvascular lesions with decreased vascular flow and increased bone fragility

Glomerular Hyperfiltration in Diabetes: Mechanisms, Clinical Significance, and Treatment

For comparison, 70% of ACA Marketplace plans use at least 1 utilization management strategy with Xarelto (covered on 97% of formularies), a similarly priced oral anticoagulant with no generic formulation available