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This discrepancy between results in animal models and clinical studies may partly be due to myocardial insulin resistance in severely failing hearts and the use of beta-blockers [21]

Studies examining patients on antidepressants who started GLP-1 receptor agonists found that those on bupropion specifically tended to fare better in terms of weight loss compared to those on SSRIs like sertraline or fluoxetine

In contrast, many hyperplastic C cells and medullary thyroid carcinomas in humans express GLP-1R

Hunger was unbearable for me

And yet the scale barely moves, or worse, the weight comes right back

This phenomenon is also not thought to be a direct toxic effect of the drug itself, but rather a known risk associated with rapid and substantial improvement in glycemic control, which can also be observed with the initiation of intensive insulin therapy