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Description
Accompanying the inward movement of GIPR ECL1 by 6.4 relative to that of GCGR (measured by C of G202 ECL1 in GIPR and G207 ECL1 in GCGR), the C terminus of peptide 20 bound by GIPR shifted toward the TMD core by 8.1 (measured by C of L27 P ) and consequently pushed the extracellular tip of TM1 towards TM7 by 2.8 (measured by C of the residues at 1.29b)

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These medications work by mimicking the action of naturally occurring incretin hormones, which enhances glucose-dependent insulin secretion, suppresses glucagon release, slows gastric emptying, and promotes satiety through central nervous system pathways

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