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As the last step of filtering, we predicted the secondary structure for each final candidate using PSIPRED 48 ( to confirm that the selected sequences are helical peptides

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Most side effects are mild and improve as the body adjusts to the medication

However, obesity and prolonged exposure to a HFD impair this process by decreasing specific leptin transporters and compromising the integrity of the BBB, ultimately obstructing leptins ability to cross into the brain and exert its anorexigenic effects (6)