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At the end of the study, mice underwent a final post-study retro-orbital bleed, and brains, separated into forebrain and hindbrain (around 3.87 mm from bregma) and inguinal and epididymal WATs, were frozen in liquid nitrogen

Dry Mouth (Xerostomia) Reduced appetite often leads to lower fluid intake, which can decrease saliva production

However, realistic expectations matter: semaglutide monotherapy produces an average 15-22% body weight reduction over 68 weeks in clinical trials, which is substantial and sustainable when combined with lifestyle changes

Additionally, activation of GIP receptors further enhances insulin secretion

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