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This high pressure capacity, along with the faster delivery time enabled by the low force drop-off, allows for delivery of high-viscosity drug formulations

For the first time, Wang et al

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Therefore, the addition of glucose-lowering agents is recommended by the American and European Diabetes Associations to control and/or minimize the risk of cardiovascular disease and microvascular complications [103]

In previous large-scale clinical trials of GLP-1RAs, 15.2% ( n = 618) of AMPLITUDE-O and 6.1% ( n = 575) of Harmony Outcomes patients used SGLT2is at baseline [18, 20] (Table 1)