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Blood pressure-lowering effects of incretin-based diabetes therapies

Both the Food and Drug Administration and European medical officials have also denied claims Ozempic could result in an increased risk of suicidal thoughts

These effects are seen even outside of diabetes control.[ref] Decreased colon cancer mortality: A 5-year mortality study in colon cancer patients showed that GLP-1 RA use decreased mortality risk by 60% in obese patients.[ref] Decreased risk of substance abuse: A large 2026 study using data from the VA showed that GLP-1 RA drugs reduce the risk of developing a substance addiction (drugs, alcohol)

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These compound-specific effects could affect the way in which individual DPP4i are used therapeutically and potentially explain off-target adverse effects, such as hospitalization for heart failure, which is seen only with one DPP4i

The patent describes a method of nucleic acid immunization used by the Amgen team to stimulate a specific immune response against mouse GIPR (Gastric Inhibitory Polypeptide Receptor) in mice