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GLP-1s may help with OA by: Reducing overall inflammation Protecting cartilage in your joints Helping people lose weight takes pressure off the knees and hips Making walking and movement easier over time Studies found that GLP-1 and SGLT2 medicines may lower the risk of needing a knee replacement (for OA), though results varied

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Neuroinflammation in Depression and Its Relation to GLP-1 The immune system in the CNS has been shown to regulate brain development, neurogenesis, mood, and behavior (Zheng et al., 2016

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Potential safety issues Pancreatic and thyroid risk Beyond gastrointestinal adverse events, which are widely accepted as a class effect of GLP-1 RAs, 65 , 66 several other safety concerns have been raised over the past decade

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As evidenced in the SURPASS trials, this novel GIP/GLP-1 dual-acting hormone therapy is yielding significant improvements in A1c and weight loss

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Results One of the central outcomes of this study was to understand the influence of allulose on altering body weight changes and food consumption, including adding to the mediating mechanisms of such changes

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The impact of obesity on outcomes following major surgery for Crohns disease: an American College of Surgeons National Surgical Quality Improvement Program assessment

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