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Drugmaker Eli Lilly announced the FDA approved its oral GLP-1 pill, called Foundayo.

Millions take GLP-1 medications, but few know their oral side effects

Glucagon-like peptide-1 (GLP-1) receptor agonists (RAs) are emerging glucose-lowering agents primarily used in managing diabetes and obesity

May 27, 2026

Retention of glucagon function is required to achieve such an advantage over GLP-1 monotherapy

Additionally, several key clinical trial readouts delivered compelling data across multiple indications, for example (see Figure 1): Semaglutide: STEP-HFpEF (functional benefits in HFpEF), STEP-9 (pain reduction in knee osteoarthritis), STEP-10 (reversion to normoglycaemia in pre-diabetic, obese patients), ESSENCE (resolution of MASH, improvement in fibrosis) Tirzepatide: SUMMIT (risk reduction in HFpEF outcomes