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The diabetes control and complications trial/epidemiology of diabetes interventions and complications study at 30 years: overview

Avoid excessive cardio, as it can increase muscle loss and elevate cortisol, which may hinder weight loss

Tirzepatide outperforms semaglutide for weight loss and blood sugar control in most clinical settings

Why It Works: GLP-1 and GIP reduce hunger and improve insulin sensitivity Glucagon receptor activation increases energy expenditure and fat oxidation 2

For most people using tirzepatide at home, the upper arm is best reserved as a backup option when someone else can administer the injection or when both primary sites need a rest
