glp 1 drugs pros and cons The Benefits of GLP-1 Therapy: Beyond Weight Loss The Pros, Cons, and Considerations

62.9% of patients achieved more than 20% weight loss compared to 1.3% on lifestyle changes alone

The global burden has increased substantially over the last twenty years, mirroring the parallel epidemics of obesity and type 2 diabetes mellitus

It acts on G-protein coupled receptors mostly expressed in pancreatic -cells, but is also found in adipose tissue, stomach, and bone [19]

Studies have shown that many people regain a lot of the lost weight within months of stopping, especially if they go back to old eating patterns

Phentermine increases heart rate and blood pressure through sympathomimetic activity, while GLP-1 agonists have shown mixed cardiovascular effectsbenefits in diabetic populations but potential concerns in certain patient subgroups, particularly those with a history of thyroid cancer or multiple endocrine neoplasia

Women of childbearing potential should use effective contraception while taking GLP-1 medications, and semaglutide should be discontinued at least 2 months before a planned pregnancy