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Aaron Uydess: Its a great question, but a complex one

The gastrointestinal effects of semaglutidelike nausea, constipation, and delayed gastric emptyingare common side effects that theoretically could contribute to appendicitis through fecalith formation

Thus, neither the tumor growth inhibitory effects nor the immune-enhancing effects of tirzepatide observed in obese mice were evident in metabolically healthy lean mice

Increase in energy expenditure and metabolic rate

[32] [33] Off-label medications with evidence supporting their use include other SSRIs and serotonin-norepinephrine reuptake inhibitors (SNRIs) such as venlafaxine and desvenlafaxine, gabapentin, and oxybutynin (with caution regarding anticholinergic side effects)

The weight loss effects are inappropriate during pregnancy and lactation when adequate nutrition is critical