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10.1016/j.tem.2016.03.017 17 ChenL.YunY.GuoS.WangX.XiongM.ZhaoT.et al (2023)

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The plasma concentration of tirzepatide after IV injection followed a multi-exponential decline, as indicated by more than one linear phase in the semi-log plot of plasma concentration versus time

This dual-hormone action is why tirzepatide tends to produce faster, greater weight loss than semaglutide for many patients

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Overall, semaglutide appeared to demonstrate enhanced efficacy in patients over 60 years of age and those with longer treatment durations