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Conversely, frequent diarrhoeaanother common Wegovy side effectmay irritate the anal area and contribute to inflammation, though this is a less established mechanism for haemorrhoid development

[DOI] [PubMed] [Google Scholar] 6.Erichsen J.M., Fadel J.R., Reagan L.P

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however, this program was discontinued in April 2025 following a potential drug-induced liver injury signal and earlier tolerability concerns, leaving orforglipron as the leading oral small-molecule GLP-1RA in late-stage development