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Tailored strategies by payer segment are essential

It also raises cortisol, which can lead to fat storage especially around the belly

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This interval aligns with recommendations from the Bone Health and Osteoporosis Foundation (BHOF) and allows sufficient time to detect clinically meaningful changes in bone density while enabling timely intervention if significant loss is identified

Design In the obesity trial, 338 participants (mean age 48 years, 48% women, mean BMI 37.3 kg/m 2 ) were randomised (2:1:1:1:1:2:2) to retatrutide 1 mg, 4 mg (titration), 4 mg (no titration), 8 mg (slow titration), 8 mg (fast titration), 12 mg or placebo over 48 weeks [45]