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The extensive SUSTAIN and STEP clinical trial programmes, which evaluated semaglutide's safety and efficacy, have not shown a signal for increased incidence of gastrointestinal bleeding compared to placebo or active comparators, as documented in the European Medicines Agency's European Public Assessment Report (EPAR)

Contact your doctor if you notice any of these symptoms: Pain that worsens after the first day (discomfort should gradually ease)

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The shared mechanism that produces both the therapeutic effect and most of the GI side effects is delayed gastric emptying