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In November 2023, a new GLP-1, called tirzepatide (Zepbound, Mounjaro), was approved for weight loss and obesity management

Zhimin Z, Jirui Y, Qiongli Z, Shiyin Z, Jinghao L, Xueting C, Jingjing L, Xin Z, Xuhong C, HuiW

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Such findings seem counterintuitive considering that the KO of H3Rs should remove the auto-inhibition of the histaminergic neurons and enhance anorexigenic actions at the H1R

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