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We hypothesize that a UTI will exacerbate neuroinflammation in aging Hartley guinea pigs, and treatment with antibiotics may mitigate long-term neurotoxic effects by alleviating inflammation

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Additionally, the caloric deficit created by reduced food intake means less energy is available for thermogenesis, the process by which the body produces heat

AMPK5 adenosine monophosphate-activated protein kinase