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Fluid Retention and Heart Failure with Concomitant Use of PPAR-gamma Agonists: Fluid retention and heart failure can occur with concomitant use of thiazolidinediones (TZDs), which are PPAR-gamma agonists, and insulin, including NovoLog Mix 70/30

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In fact, a 2022 study found that approximately one year after stopping semaglutide treatment, patients had already regained the weight they lost