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Evidence Summary: What the Data Suggest Several phase 2 and observational studies highlight the hepatic benefits of GLP1based treatment: Reduced liver fat: Repeated findings in imaging-based studies support this effect Lower liver enzymes: Consistent reductions in ALT/AST levels Fibrosis improvement: Promising trends in noninvasive markers, though further trials are needed While the strongest evidence comes from patients with obesity or type 2 diabetes, benefits in leaner, metabolically abnormal patients are increasingly documented, suggesting broader utility

doi: 10.1210/endo.138.6.9104

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market estimated to exceed $1 billion annually. Compared with other approved drugs on the market, Unloxcyt could be a differentiated option by targeting PD-L1 rather than PD-1 and because it can induce antibody-dependent cell-mediated cytotoxicity, Oliviero added

For these reasons, patients with depression must be accurately treated, and research aimed at preventing the onset of depression is therefore critical