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Controlling high blood sugar helps prevent kidney damage, blindness, nerve problems, loss of limbs, and sexual function problems

When you stay on a lower dose, you keep some of the medicine's effects on your hunger and how your body uses energy

Patients experiencing this may prefer evening administration to avoid daytime lethargy affecting work or daily activities

The long-term safety profile will not be fully established until larger and longer trials are completed

1 Introduction Glucagon-like peptide-1 (GLP-1) is an incretin hormone released from gut enteroendocrine cells and regulates blood sugar by increasing insulin while reducing glucagon secretion and inhibiting stomach emptying and food intake ( Ocular diseases, including glaucoma, diabetic retinopathy (DR), and age-related macular degeneration (AMD), impose a staggering global burden, with glaucoma alone affecting 95 million individuals and causing irreversible vision loss in over 10 million ( Emerging evidence positions GLP-1RAs as a transformative candidate for ocular therapeutics

If Im treating a diabetic patient on metformin who wants to try semaglutide, I usually add it and continue metformin until I see how their glucose levels respond, says Jennifer Brown, DO, ABOM, ABFM, a board-certified obesity and family medicine specialist at Maxwelton Health Center in West Virginia