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Retatrutide has GLP-1 activity, but it is not only a GLP-1 drug
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GLP-1 mediates its effects by binding to its receptor, the GLP-1 receptor (GLP-1R), which is a G proteincoupled receptor that is abundantly present in the pancreatic beta cells, gut, and the central nervous system (CNS) and moderately in the lung, heart, kidney, blood vessels, pancreatic alpha cells, and peripheral nervous system 2,4,7

Some people believe that the insulin response to carbs causes your body to release insulin, making you fat (i.e., the carbohydrate-insulin hypothesis of obesity)
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according to the Mayo Clinic, ensuring that your rate of weight loss doesnt exceed about two pounds per week
