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Description
This rapid degradation of GLP-1 has motivated the development of long-acting GLP-1R agonists, which are protected from DPP-IV degradation and can be used clinically (Kalra et al., 2021)
doi: 10.1007/s11064-017-2250-8
berschssiges Krperfett, insbesondere im Bauchbereich, kann zu chronischen Entzndungen fhren, die die GLP-1-Signalbertragung stren
Activation of murine pre-proglucagon-producing neurons reduces food intake and body weight
Glucagon-like peptide 1 receptor agonists: Cardiovascular benefits and mechanisms of action
In turn, cAMP further activates protein kinase A (PKA) and Rap guanine nucleotide exchange factor 4 (RAPGEF4, also known as EPAC2) (14)
