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These receptors exist on pancreatic beta cells (which produce insulin), brain regions controlling appetite and reward, the stomaComparing Mechanisms of Actionch and intestines, liver, heart, and other tissues
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10.1016/S0140-6736(16)31679-8 [DOI] [PMC free article] [PubMed] [Google Scholar] 54.Blood Pressure Lowering Treatment Trialists Collaboration
While the weight loss itself often benefits the system, the impact of GLP-1s on reproductive hormones and cycle is a complex area, and it is imperative to use strict contraception and stop treatment immediately if attempting to conceive or upon becoming pregnant due to potential GLP-1 fertility concerns
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Certain FDA-approved oral options also offer low cost pricing through self-pay programs
