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251 Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of IBI362 in Overweight or Obesity Subjects
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Butyrate can downregulate GPX4 and SLC7A11 via the FFAR2mTORC1 axis, thereby promoting ferroptosis (85, 86), constituting a direct intervention on the GPX4-GSH system
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181,182 Poor sleep is associated with insulin resistance, increased hunger, and weight gain, which might reduce some benefits of GLP-1s
