semaglutide and crohn's Glucagon-like peptide-1 (GLP-1) receptor agonists in inflammatory bowel disease: mechanisms, clinical implications, therapeutic potential GLP-1R Agonists and Their Therapeutic

Rapid Weight Loss and Skeletal Stress The most common explanation for joint pain during semaglutide therapy is metabolic stress from rapid weight loss

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Deganutti G, Liang YL, Zhang X, Khoshouei M, Clydesdale L, Belousoff MJ, et al

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NICE approved semaglutide (Wegovy) for weight management in specialist NHS weight management services in 2023 (TA875), but availability is limited to patients with: BMI 35 kg/m with at least one weight-related comorbidity, or BMI 30 kg/m with exceptional circumstances Lower BMI thresholds apply for people from some minority ethnic groups (typically 27.5 kg/m) Participation in a specialist weight management programme Treatment limited to a maximum of 2 years Access varies by region due to local integrated care board (ICB) implementation decisions and limited NHS specialist service capacity