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This makes it tough for GLP-1 receptors to work

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In contrast with GLP-1, there is a glycine at the second amino acid position in the N-terminus of Ex-4 that can protect the peptide against inactivation and degradation mediated by DPP-4 (130)

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This is especially true if you have a BMI of 30 or higher, have difficulty with hunger and cravings, or have weight-related metabolic conditions such as type 2 diabetes or prediabetes