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Semaglutide (Ozempic/Wegovy) is closer to 15%

Clinical trials reveal that tirzepatide (Mounjaro) leads the pack, achieving 15-20% body weight reduction , outperforming both Wegovy and other GLP-1 weight loss medications

While semaglutide has not been studied in a dedicated OSA trial of this scale, the weight loss it produces likely offers similar benefits, since the primary mechanism is fat reduction around the airway and abdomen

Details of the National Institutes of Health-funded study were published this week in a Nature paper titled A brain reward circuit inhibited by next-generation weight-loss drugs in mice. In it, the team reported that they investigated the small-molecule GLP-1s including Eli Lillys recently approved drug orforglipron, also known by the brand name Foundayo, as well as danuglipron, an oral GLP-1 that was being developed by Pfizer until the company decided to discontinue its development in 2025
Once the drugs are approved for use, they must be monitored carefully for any new adverse events and to ensure they continue to be effective at controlling diabetes over time [42]

Available from Accessed 9 Apr 2025 Ludvigsson JF, Andersson E, Ekbom A et al (2011) External review and validation of the Swedish national inpatient register
