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This guide explains when to stop semaglutide, tirzepatide, or liraglutide before trying to conceive, how long to wait during the washout period, what current research shows about pregnancy safety, and how to maintain your weight loss and fertility while you prepare for a healthy pregnancy

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[1] Clinical trials demonstrate that most patients experience substantial weight loss during treatment, with average reductions of 15-21% of initial body weight at maximum doses by approximately 72 weeks, as shown in the SURMOUNT-1 trial

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This low starting dose allows your body to adjust to the medication while still providing noticeable appetite changes for most users

TABLE 1 Summary of the mechanisms of action and effects of GLP-1R agonists in AD