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And these drugs have been used for diabetes for over a decade so safety is well understood

Fasting blood glucose (FBG) was reported as Mean SE in that article and SD was calculated to be used in GPower 3.1

doi: 10.3389/fendo.2021.721135 14 DruckerDJ

You are simply compressing one interval by 24 hours, and the pharmacokinetics accommodate that compression without any meaningful change in drug levels

The risk of NAION is very rare compared to the massive reduction in cardiovascular events and overall mortality seen in GLP-1 trials

Of course, there can be downsides, such as possibly feeling disconnected from a cultural tradition or social event that revolves around food