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[DOI] [PMC free article] [PubMed] [Google Scholar] 80.Stoker T

Transitioning to a lower maintenance dose rather than stopping abruptly may preserve more of the weight loss, though long-term data on this approach is still emerging

Given this huge number, NHS England requested a funding variation to extend the time needed to comply with the recommendations, which NICE accepted

Breathing difficulty , especially when lying flat or during mild exertion, combined with weight gain is a potential sign of fluid accumulation around the lungs (pleural effusion) or worsening heart function

Dopo il periodo di trattamento di 72 settimane, i partecipanti che non avevano avuto prediabete al momento della randomizzazione sono passati a un periodo di follow-up sulla sicurezza di 4 settimane

Warnings and Precautions 5.1 Risk of Thyroid C-Cell Tumors In rats, tirzepatide caused a dose-dependent and treatment-duration-dependent increase in the incidence of thyroid C-cell tumors (adenomas and carcinomas) in a 2-year study at clinically relevant plasma exposures [see Nonclinical Toxicology (13.1)]