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The LEADER trial, a landmark study, has provided compelling evidence of its cardiovascular benefits [7]

The findings appeared on July 22, 2025 in BMJ Open Diabetes Research & Care Given the severe societal, familial, and economic burden of diabetes-related dementia, these findings raise important considerations about the role of GLP-1 [receptor agonists] as first-line therapies in [type 2 diabetes] management, the authors said
Thus, the elucidation of whether the SGLT2-i diuretic effect can influence ARR values for PA screening in patients with diabetes and hypertension is an important clinical issue
