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This novel mechanism distinguishes it from single-receptor GLP-1 agonists by targeting two complementary pathways involved in glucose homeostasis and appetite regulation

Stop and contact your doctor immediately if you experience severe abdominal pain, signs of dehydration, vomiting that lasts more than 24 hours, or any symptoms that interfere significantly with daily life

The following adverse effects were reported in patients receiving semaglutide injection or oral tablets across all clinical trials and at incidences higher than with placebo: nausea (11% to 44%), vomiting (5% to 24%), diarrhea (8.5% to 30%), abdominal pain (5.7% to 20%), abdominal distention (2% to 7%), constipation (3.1% to 24%), dyspepsia (0.6% to 9%), decreased appetite (6% to 9%), eructation (0.6% to 7%), flatulence (0.4% to 6%), gastroesophageal reflux disease (1.5% to 5%), gastroenteritis (4% to 6%), and gastritis (0.4% to 4%)