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The results were promising as the primary composite outcome (first occurrence of three-point MACE) occurred in 608 out of the 4668 patients (13.0%) treated with liraglutide as compared to 694 out of the 4672 patients (14.9%) in the placebo group

NICE technology appraisal guidance TA875 supports the use of semaglutide 2.4 mg (Wegovy) for adults who meet specific criteria: BMI 35 kg/m with at least one weight-related comorbidity (such as type 2 diabetes, hypertension, or obstructive sleep apnoea) BMI 3034.9 kg/m in certain higher-risk groups For people from certain ethnic backgrounds including South Asian, Chinese, other Asian, Middle Eastern, Black African, and African-Caribbean groups lower BMI thresholds apply (typically approximately 2.5 kg/m lower than standard thresholds), in line with NHS and NICE guidance on ethnicity-related metabolic risk Treatment must be delivered as part of a specialist weight management service providing multidisciplinary support Treatment duration under TA875 is limited to a maximum of 2 years Should retatrutide receive regulatory approval and a positive NICE appraisal, it is likely that similar eligibility criteria would apply, potentially with additional considerations given its more potent mechanism of action

Beyond individual predictions, such models could help health systems anticipate population-level demand and plan services more effectively

As a result, those with endocrine system conditions are not advised to take Ozempic or Wegovy