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A 2025 review on the effects of weight cycling on muscle and sarcopenia suggested that it may lead to disproportionate fat regain, reduced FFM, accelerated age-related muscle loss and an increased risk for functional impairment and disability, particularly in older or frail individuals, contributing to worsened muscle health outcomes including sarcopenic obesity [14]

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Caffeine (10 mg/kg/day, p.o.) and coffee (caffeine dose 286 mg/kg/day, p.o.) treatments were started at the second day of STZ-induced diabetes and performed for 7 weeks in male rats

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