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This bidirectional signaling pathway connecting the gastrointestinal tract and the central nervous system involves mechanisms associated with the intestinal peptides, in particular human incretin hormones such as anorexigenic GLP-1

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p = 0.022), especially in patients at high CV risk (age 65 years, T2D duration 10 years and BMI 30 kg/m 2 ), but not the other DPP-4is, suggesting a differential effect of each DPP-4 inhibitor on the risk of HF [151]

Reddit users, however, have been discussing access and coverage long before the policy change made headlines

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