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This conformation causes retatrutide to straighten, shifting its tip towards the TMD core by 4.29 and 4.13 (measured by the C of L27 P ), relative to GLP-1R and GCGR, respectively

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[DOI] [PMC free article] [PubMed] [Google Scholar] 9.Iwasaki Y., Sendo M., Dezaki K., Hira T., Sato T., Nakata M., Goswami C., Aoki R., Arai T., Kumari P., et al