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Tirzepatide Toxicity and Safety Tirzepatide is generally well tolerated, but its toxicity profile warrants systematic evaluation

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Kochhar GS, Khataniar H, Jairath V, Farraye FA, Desai A

In clinical trials: Semaglutide: Approximately 7% discontinued due to adverse events Tirzepatide: Approximately 4-7% discontinued due to adverse events (dose dependent) Retatrutide: Approximately 6-10% discontinued due to adverse events (dose dependent) These rates are relatively close, suggesting that despite the differences in mechanism and side effect profiles, all three medications are tolerable for the vast majority of people who start them

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Is tirzepatide safe to resume after a long gap, or do I need to restart at a lower dose